GLEAM-DB

Search GLEAM-DB / CoGenEx-PM3

GLEAM-DB is the Genomic Literature Evidence Atlas Map. The current public release implements CoGenEx-PM3, a PM3 evidence module for literature-derived allelic-configuration evidence.

Search returns PMID × variant evidence records, not final variant classifications. GLEAM-DB does not provide medical advice or replace expert interpretation.

Supported query types

Example queries

PM3-related evidence-rich example Variant: NM_000277.3:c.158G>A Gene: PAH Record type: Phase-confirmed and phase-unconfirmed records Demonstrates evidence-first sorting where retained evidence explicitly contains the query variant.
Gene:c.HGVS example Variant: PAH:c.158G>A Gene: PAH Record type: Gene-constrained c.HGVS retrieval Shows the same VUS target through gene-constrained c.HGVS search.
Phase-confirmed example Variant: NM_000298.6:c.1706G>A Gene: PKLR Record type: Phase-confirmed PM3 evidence Shows confirmed in-trans evidence with retained partner variants.
Other patient-level evidence example Variant: NM_000350.3:c.2473G>A Gene: ABCA4 Record type: Other Patient-Level Evidence Shows patient-level evidence that is not classified as PM3 evidence.
No PM3 evidence example Variant: NM_000059.4:c.520C>G Gene: BRCA2 Record type: No PM3 Evidence Identified Shows a negative PMID × variant audit result as a boundary case.
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