/* Source Serif 4: self-hosted (OFL); files from db_build/website/Source_Serif_4.zip */
@font-face {
  font-family: "Source Serif 4";
  font-style: normal;
  font-weight: 400;
  font-display: swap;
  src: url("../fonts/source-serif-4/SourceSerif4-Regular.ttf") format("truetype");
}

@font-face {
  font-family: "Source Serif 4";
  font-style: normal;
  font-weight: 600;
  font-display: swap;
  src: url("../fonts/source-serif-4/SourceSerif4-SemiBold.ttf") format("truetype");
}

@font-face {
  font-family: "Source Serif 4";
  font-style: italic;
  font-weight: 400;
  font-display: swap;
  src: url("../fonts/source-serif-4/SourceSerif4-Italic.ttf") format("truetype");
}

:root {
  --bg: #f7f8f5;
  --panel: #ffffff;
  --ink: #17211b;
  --muted: #637065;
  --line: #d8ded6;
  --accent: #1c5f4a;
  --accent-soft: #e8f2ee;
  /* Academic DB typography: serif body, sans UI, mono IDs/HGVS */
  --font-serif: "Source Serif 4", "Noto Serif", "Times New Roman", Times, serif;
  --font-ui: "Source Sans 3", system-ui, -apple-system, "Segoe UI", Roboto, sans-serif;
  --font-mono: "IBM Plex Mono", Consolas, "Liberation Mono", Menlo, monospace;
}

* {
  box-sizing: border-box;
}

html {
  font-size: 100%;
}

body {
  margin: 0;
  background: var(--bg);
  color: var(--ink);
  font-family: var(--font-serif);
  font-size: 1.0625rem;
  line-height: 1.6;
  font-optical-sizing: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  /* Lining + tabular figures in prose and tables (Source Serif 4 supports both) */
  font-variant-numeric: lining-nums tabular-nums;
  font-feature-settings: "lnum" 1, "tnum" 1;
}

a {
  color: var(--accent);
}

h1,
h2,
h3 {
  font-family: var(--font-serif);
  font-weight: 600;
  line-height: 1.3;
}

.site-header {
  display: flex;
  gap: 18px;
  flex-wrap: wrap;
  justify-content: space-between;
  align-items: center;
  padding: 18px 5vw;
  border-bottom: 1px solid var(--line);
  background: var(--panel);
  font-family: var(--font-ui);
  font-size: 1rem;
  line-height: 1.45;
}

.brand {
  color: var(--ink);
  font-size: 1.2rem;
  font-weight: 700;
  text-decoration: none;
}

nav a {
  display: inline-block;
  margin-left: 16px;
  text-decoration: none;
}

.container {
  max-width: 1180px;
  margin: 0 auto;
  padding: 34px 24px 56px;
}

.hero {
  padding: 34px;
  border: 1px solid var(--line);
  background: var(--panel);
}

.eyebrow,
.muted {
  color: var(--muted);
}

.lead {
  font-size: 1.2rem;
}

.search-box {
  display: flex;
  gap: 10px;
  margin: 24px 0 14px;
}

.search-box input {
  flex: 1;
  min-width: 0;
  padding: 12px 14px;
  border: 1px solid var(--line);
  font: inherit;
  font-family: var(--font-mono);
  font-size: 0.95rem;
  font-variant-numeric: tabular-nums;
  line-height: 1.4;
}

.page-size-label {
  display: flex;
  align-items: center;
  gap: 8px;
  white-space: nowrap;
  color: var(--muted);
  font-size: 0.95rem;
  font-family: var(--font-ui);
}

.page-size-label select {
  padding: 8px 10px;
  border: 1px solid var(--line);
  font: inherit;
  background: var(--panel);
}

button,
.actions a,
.pagination a {
  padding: 11px 16px;
  border: 1px solid var(--accent);
  background: var(--accent);
  color: #fff;
  font-family: var(--font-ui);
  font-size: 0.95rem;
  font-weight: 600;
  line-height: 1.3;
  text-decoration: none;
  cursor: pointer;
}

.compact {
  max-width: 760px;
}

.examples {
  display: flex;
  flex-wrap: wrap;
  gap: 10px;
  align-items: baseline;
}

.example-inline {
  display: inline;
  margin: 0;
  padding: 0;
}

.example-card-grid {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 14px;
}

.example-card {
  display: grid;
  gap: 6px;
  padding: 14px;
  border: 1px solid var(--line);
  background: #fbfcfa;
}

button.link-like {
  display: inline;
  margin: 0;
  padding: 0;
  border: none;
  background: none;
  color: var(--accent);
  font-family: var(--font-mono);
  font-size: 0.95rem;
  text-decoration: underline;
  cursor: pointer;
  vertical-align: baseline;
}

button.link-like:hover {
  text-decoration: none;
}

.filter-grid {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 14px;
  margin-top: 16px;
  font-family: var(--font-ui);
}

.filter-grid label {
  display: grid;
  gap: 4px;
  color: var(--muted);
  font-size: 0.92rem;
}

.filter-grid input,
.filter-grid select {
  width: 100%;
  padding: 9px 10px;
  border: 1px solid var(--line);
  background: var(--panel);
  color: var(--ink);
  font: inherit;
}

.filter-grid .checkbox-label {
  display: flex;
  align-items: center;
  gap: 8px;
  color: var(--ink);
}

.filter-grid .checkbox-label input {
  width: auto;
}

.filter-actions {
  display: flex;
  flex-wrap: wrap;
  gap: 10px;
  align-items: end;
  grid-column: 1 / -1;
}

.filter-actions a {
  padding: 10px 14px;
  border: 1px solid var(--accent);
  color: var(--accent);
  text-decoration: none;
}

.cards {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  gap: 16px;
  margin: 24px 0;
}

.card,
.panel,
.notice {
  border: 1px solid var(--line);
  background: var(--panel);
}

.card {
  padding: 18px;
}

.card span {
  display: block;
  color: var(--muted);
}

.card strong {
  display: block;
  margin-top: 8px;
  font-size: 1.65rem;
  font-variant-numeric: tabular-nums;
  font-feature-settings: "tnum" 1;
}

.panel {
  margin: 22px 0;
  padding: 22px;
}

.record-scope {
  margin: 0 0 20px;
  max-width: 52em;
  line-height: 1.45;
}

.panel-note {
  margin: 0 0 14px;
  max-width: 52em;
  font-size: 0.95rem;
  line-height: 1.45;
}

.id-inline {
  font-family: var(--font-mono);
  font-size: 0.9em;
  font-weight: 500;
  font-variant-numeric: tabular-nums;
  font-feature-settings: "tnum" 1, "lnum" 1;
  padding: 2px 6px;
  border-radius: 3px;
  background: #eef2ed;
}

.query-variant-text {
  display: inline-block;
  max-width: 100%;
  white-space: pre-wrap;
  word-break: break-word;
  vertical-align: top;
}

.id-link {
  margin-left: 10px;
  white-space: nowrap;
}

.notice {
  margin: 18px 0;
  padding: 14px 16px;
  background: var(--accent-soft);
}

.table-wrap {
  overflow-x: auto;
}

.evidence-table {
  min-width: 900px;
}

table {
  min-width: 900px;
  width: 100%;
  border-collapse: collapse;
  background: var(--panel);
  font-variant-numeric: lining-nums tabular-nums;
  font-feature-settings: "lnum" 1, "tnum" 1;
}

th,
td {
  padding: 10px 12px;
  border-bottom: 1px solid var(--line);
  text-align: left;
  vertical-align: top;
}

th {
  background: #eef2ed;
}

.table-note {
  margin: 0 0 12px;
  max-width: 64em;
}

.evidence-table th,
.evidence-table td {
  font-size: 0.9rem;
}

.evidence-table th:nth-child(1),
.evidence-table td:nth-child(1) {
  min-width: 68px;
  white-space: nowrap;
}

.evidence-table th:nth-child(2),
.evidence-table td:nth-child(2) {
  min-width: 210px;
}

.evidence-table th:nth-child(3),
.evidence-table td:nth-child(3) {
  min-width: 145px;
}

.evidence-table th:nth-child(4),
.evidence-table td:nth-child(4) {
  min-width: 175px;
}

.evidence-table th:nth-child(5),
.evidence-table td:nth-child(5) {
  min-width: 240px;
}

.evidence-table th:nth-child(6),
.evidence-table td:nth-child(6) {
  min-width: 64px;
  white-space: nowrap;
}

.evidence-table th:nth-child(7),
.evidence-table td:nth-child(7) {
  min-width: 108px;
  width: 108px;
}

.evidence-table .flag-cell {
  min-width: 180px;
}

.detail-link {
  display: inline-block;
  width: 100%;
  padding: 4px 7px;
  border: 1px solid var(--line);
  background: var(--panel);
  color: var(--accent);
  font-family: var(--font-ui);
  font-size: 0.78rem;
  font-weight: 700;
  line-height: 1.25;
  text-align: center;
  text-decoration: none;
  white-space: nowrap;
}

.record-actions {
  display: grid;
  grid-template-columns: 1fr;
  gap: 5px;
  align-items: stretch;
  max-width: 92px;
}

.inline-feedback-button {
  width: 100%;
  padding: 4px 7px;
  border-color: var(--line);
  background: var(--panel);
  color: var(--accent);
  font-size: 0.78rem;
  font-weight: 600;
  line-height: 1.25;
  white-space: normal;
}

.inline-feedback-button.issue {
  color: #8a4a16;
}

.inline-feedback-button:disabled {
  opacity: 0.55;
  cursor: default;
}

.inline-feedback-status {
  min-height: 1.2em;
  color: var(--muted);
  font-family: var(--font-ui);
}

.inline-feedback-status.error {
  color: #9b1c1c;
}

.feedback-detail-row td {
  background: #fbfcfa;
  border-bottom: 1px solid var(--line);
}

.inline-feedback-detail-form {
  display: grid;
  gap: 8px;
  max-width: 620px;
  font-family: var(--font-ui);
}

.inline-feedback-detail-form label {
  display: grid;
  gap: 4px;
  color: var(--muted);
  font-size: 0.9rem;
}

.inline-feedback-detail-form textarea {
  min-height: 72px;
  padding: 8px 10px;
  border: 1px solid var(--line);
  font: inherit;
  color: var(--ink);
  background: var(--panel);
}

.inline-feedback-detail-actions {
  display: flex;
  gap: 10px;
  align-items: center;
}

.inline-feedback-detail-actions button {
  padding: 7px 10px;
  font-size: 0.85rem;
}

.gene-summary-section {
  margin: 20px 0 24px;
}

.gene-summary-grid {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 14px;
}

.gene-summary-card {
  border: 1px solid var(--line);
  background: var(--panel);
  padding: 16px;
}

.gene-summary-card h3 {
  margin: 0 0 10px;
}

.gene-summary-card dl {
  display: grid;
  grid-template-columns: minmax(0, 1fr) auto;
  gap: 6px 12px;
  margin: 0;
}

.gene-summary-card dt {
  color: var(--muted);
}

.gene-summary-card dd {
  margin: 0;
  font-weight: 600;
  font-variant-numeric: tabular-nums;
}

.gene-result-group {
  margin: 26px 0 18px;
}

.gene-result-group h2 {
  margin-bottom: 10px;
}

.small-text {
  margin-top: 4px;
  font-size: 0.86rem;
  line-height: 1.35;
}

.badge {
  display: inline-flex;
  max-width: 100%;
  padding: 5px 9px;
  border-radius: 5px;
  background: var(--accent-soft);
  color: var(--accent);
  font-family: var(--font-ui);
  font-size: 0.84rem;
  font-weight: 700;
  line-height: 1.25;
  overflow-wrap: anywhere;
}

.evidence-pm3-evidence {
  background: #dcefe5;
  color: #0f5132;
  border: 1px solid #9ccdb3;
}

.evidence-pm3-supporting {
  background: #e6f2f4;
  color: #15596b;
  border: 1px solid #a8d2dc;
}

.evidence-other-patient {
  background: #eef1f5;
  color: #3d536d;
  border: 1px solid #c8d0da;
}

.evidence-no-match {
  background: #f1f1ed;
  color: #686b63;
  border: 1px solid #d5d8cf;
}

.evidence-other-status {
  background: #f2ede1;
  color: #6b5425;
  border: 1px solid #d8caab;
}

.confidence-line {
  margin-top: 6px;
}

.confidence-high {
  background: #e3f2e8;
  color: #165c35;
  border: 1px solid #a8d4b8;
}

.confidence-medium {
  background: #fff3d6;
  color: #765714;
  border: 1px solid #e3ca87;
}

.confidence-low {
  background: #f8dfdf;
  color: #8a2f2f;
  border: 1px solid #dfa4a4;
}

.confidence-not-assessed {
  background: #eceef1;
  color: #59616c;
  border: 1px solid #c9ced5;
}

.pagination {
  display: flex;
  gap: 14px;
  align-items: center;
  margin-top: 18px;
  font-family: var(--font-ui);
  font-size: 0.95rem;
}

.detail-grid {
  display: grid;
  grid-template-columns: 180px minmax(0, 1fr);
  gap: 10px 18px;
}

.detail-grid dt {
  color: var(--muted);
  font-weight: 700;
}

.actions {
  display: flex;
  flex-wrap: wrap;
  gap: 10px;
  margin-top: 18px;
}

.compact-panel {
  max-width: 820px;
}

.search-summary {
  max-width: none;
  margin: 10px 0 12px;
  padding: 10px 12px;
}

.prose {
  max-width: 860px;
}

.summary-metrics {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  gap: 12px;
  margin-top: 18px;
}

.summary-metric {
  padding: 14px;
  border: 1px solid var(--line);
  background: #f7f9f6;
}

.summary-metric span {
  display: block;
  color: var(--muted);
  font-family: var(--font-ui);
  font-size: 0.9rem;
  line-height: 1.35;
}

.summary-metric strong {
  display: block;
  margin-top: 6px;
  font-size: 1.35rem;
  font-variant-numeric: lining-nums tabular-nums;
  font-feature-settings: "lnum" 1, "tnum" 1;
}

.metric-line,
.definition-row {
  display: flex;
  justify-content: space-between;
  gap: 18px;
  padding: 8px 0;
  border-bottom: 1px solid var(--line);
}

.definition-row {
  justify-content: flex-start;
}

.definition-row code {
  flex: 0 0 230px;
}

.metric-line strong {
  font-variant-numeric: tabular-nums;
}

.schema-flow {
  display: flex;
  flex-wrap: wrap;
  gap: 10px;
  margin: 14px 0;
  font-family: var(--font-ui);
}

.schema-flow span {
  padding: 10px 12px;
  border: 1px solid var(--line);
  background: var(--accent-soft);
}

.schema-flow span:not(:last-child)::after {
  content: "→";
  margin-left: 12px;
  color: var(--muted);
}

.inline-list {
  margin: 0;
  padding-left: 18px;
}

.feedback-form {
  display: grid;
  gap: 12px;
  max-width: 640px;
}

textarea {
  min-height: 120px;
  padding: 12px;
  border: 1px solid var(--line);
  font-family: var(--font-ui);
  font-size: 0.95rem;
  line-height: 1.45;
}

.stats-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 18px;
}

.stats-grid-secondary .panel {
  margin: 0;
}

.stat-panel-wide {
  max-width: 940px;
}

.stat-chart {
  width: min(100%, 388px);
  max-width: 388px;
}

.stat-chart-wide {
  width: 100%;
  max-width: 820px;
}

.stat-chart-header,
.stat-chart-row {
  display: grid;
  grid-template-columns: 142px 150px 72px;
  gap: 12px;
  align-items: center;
}

.stat-chart-wide .stat-chart-header,
.stat-chart-wide .stat-chart-row {
  grid-template-columns: minmax(260px, 1.4fr) minmax(220px, 1fr) 88px;
}

.stat-chart-header {
  padding: 8px 10px;
  background: #eef2ed;
  font-weight: 600;
}

.stat-chart-row {
  padding: 8px 10px;
  border-bottom: 1px solid var(--line);
}

.stat-chart-header > *,
.stat-chart-row > * {
  min-width: 0;
}

.stat-label {
  white-space: normal;
  overflow: visible;
  text-overflow: clip;
  line-height: 1.35;
}

.stat-bar-meter {
  appearance: none;
  -webkit-appearance: none;
  accent-color: var(--accent);
  color: var(--accent);
  width: 150px;
  max-width: 150px;
  height: 10px;
  border: 0;
  border-radius: 2px;
  background: var(--line);
  overflow: hidden;
}

.stat-chart-wide .stat-bar-meter {
  width: 100%;
  max-width: none;
}

.stat-bar-meter::-webkit-progress-bar {
  border-radius: 2px;
  background: var(--line);
}

.stat-bar-meter::-webkit-progress-value {
  border-radius: 2px;
  background: var(--accent);
}

.stat-bar-meter::-moz-progress-bar {
  border-radius: 2px;
  background: var(--accent);
}

.stat-count {
  text-align: right;
  white-space: nowrap;
  font-variant-numeric: tabular-nums;
  font-feature-settings: "tnum" 1;
}

@media (max-width: 760px) {
  .site-header,
  .search-box {
    display: block;
  }

  nav a {
    display: inline-block;
    margin: 10px 16px 0 0;
  }

  .cards,
  .summary-metrics,
  .stats-grid,
  .example-card-grid,
  .filter-grid,
  .gene-summary-grid,
  .detail-grid {
    grid-template-columns: 1fr;
  }

  .stat-chart-wide .stat-chart-header,
  .stat-chart-wide .stat-chart-row {
    grid-template-columns: minmax(0, 1fr) 110px 72px;
  }

  button {
    margin-top: 10px;
  }
}

.summary-grid {
  display: flex;
  flex-wrap: wrap;
  gap: 6px 18px;
  align-items: baseline;
}

.summary-item {
  display: flex;
  flex-direction: row;
  gap: 6px;
  align-items: baseline;
}

.summary-label {
  color: var(--muted);
  font-size: 0.8rem;
  font-family: var(--font-ui);
  white-space: nowrap;
}

.summary-value {
  font-weight: 600;
  font-size: 0.9rem;
}